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Since 2004, nanoComposix has provided monodisperse and unagglomerated silver nanoparticles to thousands of customers. Hundreds of different variants of size, shape, and surface are available as stock products and we have produced over 2000 custom core/shell, biofunctionalized, fluorescent, and antimicrobial silver nanocomposites to meet client specifications.




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Silver nanopaticles are widely incorporated into wound dressings, and are used as an antiseptic and disinfectant in medical applications and in consumer goods. Silver nanoparticles have a high surface area per unit mass and release a continuous level of silver ions into their environment. The silver ions are bioactive and have broad spectrum antimicrobial properties against a wide range of bacteria. By controlling the size, shape, surface and agglomeration state of the nanoparticles, specific silver ion release profiles can be developed for a given application.


Incorporation of silver particles into plastics, composites, and adhesives increases the electrical conductivity of the material. Silver pastes and epoxies are widely utilized in the electronics industries. Silver nanoparticle based inks are used to print flexible electronics and have the advantage that the melting point of the small silver nanoparticles in the ink is reduced by hundreds of degrees compared to bulk silver. When scintered, these silver nanoparticle based inks have excellent conductivity.


Silver nanoparticles have unique optical properties because they support surface plasmons. At specific wavelengths of light the surface plasmons are driven into resonance and strongly absorb or scatter incident light. This effect is so strong that it allows for individual nanoparticles as small as 20 nm in diameter to be imaged using a conventional dark field microscope. This strong coupling of metal nanostructures with light is the basis for the new field of plasmonics. Applications of plasmonic silver nanoparticles include biomedical labels, sensors, and detectors. It is also the basis for analysis techniques such as Surface Enhanced Raman Spectroscopy (SERS) and Surface Enhanced Fluorescent Spectroscopy.


There is increasing interest in utilizing the large scattering and absorption cross sections of plasmonic silver nanoparticles for solar applications. Since the nanoparticles act as efficient optical antennas, very high efficiencies can be obtained when the nanoparticles are incorporated into collectors.


Each batch of silver nanoparticles is extensively characterized using techniques including transmission electron microscopy (TEM), dynamic light scattering (DLS), zeta potential, and UV-Visible spectroscopy. In addition to ensuring that every batch of nanoparticles meets our stringent quality control requirements, customers are provided with batch-specific specification sheets containing representative TEM images, sizing data, hydrodynamic diameter measurements, zeta potential analysis, UV-Visible spectrum, and solution pH.


Silver nanoparticles are provided in two concentrations, NanoXact (0.02 mg/mL) and BioPure (1 mg/mL). At NanoXact concentration, the silver particles are a pale orange or yellow color in solution depending on their size. The BioPure formulation is 50-times more concentrated, extensively purified to remove residual reactants, and opaque. The highly concentrated BioPure formulations are ideal for applications that require high concentrations or low residual reactants including nanotoxicology, environmental studies, and lateral flow assays.Large silver nanoparticles may settle out of solution, but are easily redispersed by simply shaking the storage vial.


Due to their small size and low mass, once nanoparticles bind together it is often impossible to separate them. Consequently, most dried silver nanopowders that are resuspended consist of clusters of 100's of individual nanoparticles. For many plasmonics and biomedical applications, this agglomeration significantly degrades performance. At nanoComposix we have developed custom processing techniques that allow us to concentrate and purify nanoparticles without inducing agglomeration. The particles can be transferred into a variety of different solvents to enable their integration into a wide variety of systems. In addition, we have developed a surface stabilization technique that allows us to produce dried silver nanoparticles that can be redispersed into individual, monodisperse nanoparticles.


A colloid is a mixture of two substances. One part of the blend is split into tiny pieces and mixed into the other part. Colloidal silver is made up of tiny particles of silver in water. The bits of silver are so small they stay afloat in the liquid.


But many companies market colloidal silver supplements as cure-all products. They claim it can boost your immune system, ease chest congestion, and treat or prevent viral infections like the common cold or COVID-19. You might also hear that colloidal silver helps treat conditions like cancer, HIV and AIDS, shingles, herpes, or eye problems. But these statements are not backed by research.


Silver is an ingredient in some treatments you put on your skin, such as bandages or creams that treat burns, wounds, or skin infections. But unlike colloidal silver supplements that you take by mouth or inject into a vein, these skin treatments are proven to work well and are approved by the FDA.


Missouri televangelist Jim Bakker was ordered to pay $156,000 in restitution to the viewers of his religious talk show. This was for touting a fake COVID cure called the "Silver Solution" that contained colloidal silver, an ingredient which health authorities warn can be toxic and cause permanent skin discoloration.


Colloidal silver is a commercially sold product that contains microscopic flakes of pure silver. Usually the flakes are suspended in demineralized water or another liquid. This form is marketed for oral use.


Topical colloidal silver products claim to be antimicrobial, germ-fighting agents. At least one clinical study indicates that this claim may be questionable. Other studies show some promise when silver nanoparticles are incorporated into bandages and dressings for wounds.


Colloidal silver is also claimed to promote healing of skin wounds. According to a 2007 study, silver-containing wound dressings are a more effective barrier against infection than other products that make similar claims.


Companies that claim that colloidal silver is a miracle cure for diseases such as cancer and HIV are doing so without any clinical proof. There are many other safe options for staying healthy, preventing disease, and getting better from illness.


According to its page on Bakker's website, Silver Solution is a product that "works faster, longer and more efficiently than other silvers to support your immune system." Information on the website does not state how the product is to be used. It currently sells on Bakker's website in a variety of packages with a 16-ounce bottle costing 40, but shoppers can purchase bundles of the product that cost up to $300. The label states that the solution contains deionized water, but no other ingredients.


However, similarly marketed products also include colloidal silver which according to the National Center for Complementary and Integrative Health (NCCIH) provides no known health benefits. Ingesting it can cause side effects including argyria, or discoloration of the skin or other tissue, and poor absorption of other medications by the body.


Even in antiquity silver was recognised, albeit anecdotally, as having antibacterial properties. Ancient romans used silver vessels, and cutlery was made in silver. In the past silver coins were placed in milk to reduce souring.


In more recent times silver in various forms has been used in bandages to aid healing and prevent infection, as well as a host of other uses such as incorporation into the surfaces of items used in kitchens and hospitals. One research document states that silver is effective against 650 strains of microorganisms. A full list of references would certainly run into several pages, here are a few examples.


This is still a hotly debated subject and more research is required, but some research suggests that it is silver Ag+ ions that have a disruptive effect on the cellular membrane leading to death of the organism.


The problem here lies in ion delivery, as ingested solutions of ionic silver become silver compounds within 7 seconds of ingestion. Silver nanoparticles can travel through the human organism whilst releasing silver ions from their surface.


This process of oxidisation is slower than the direct ionic contact method, but in the cases where free ions such as chloride may be present (blood serum etc), silver nanoparticles are an effective delivery mechanism for silver ions due to their low reactivity potential. Whether antimicrobial property derives from the actual particle or their ion releasing capacity, the result is the same.


Many of the products available on the market today called colloidal silver contain low particle concentration and often of very large particle size, together with a high ionic content. A true colloid containing over 50% particles and of a mean particle size of less than 10Nm is a massively more effective in antimicrobial activity.


The fact that the FDA allows it to be manufactured in a highly controlled facility, and to be sold to the public, supports this. Whilst there are no specific regulations relating to colloidal silver, manufacturing facilities are rigorously controlled by the FDA as with any food or pharmaceutical related process.


Ionic silver solutions are not colloids. The silver ions (silver particles missing one outer orbital electron) can only exist in the solute. Once in contact with free ions or when the water evaporates, insoluble and sometimes undesirable silver compounds will form.


Whilst they are useful in certain external applications, ionic solutions are limited by their reactive capacity. In many cases the silver compounds formed are non-effective and/or undesirable in high dosage. 041b061a72


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